Диссертация: инструкция по подготовке и защите - стр. 24

Role of hypothalamic histaminergic neurons in mediation of ACTH and beta-endorphin responses to LPS endotoxin in vivo Knigge U., Kjaer A., Jorgensen H., Gar-barg M., Ross C., Rouleau A., WarbergJ. Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark Neuroendocrinology. 1994 Sep; 60(3): 243 —51 The involvement of hypothalamic hista-minergic neurons in the mediation of the ACTH and beta-endorphin (beta-END) response to lipopolysaccharide (LPS) endotoxin was investigated in conscious male rats. LPS stimulated the release of ACTH and beta-END dose-dependently and increased the hypothalamic concentration of the histamine (HA) metabolite tele-methylhista-mine significantly and that of HA slightly, indicating an increased turnover of neuronal HA. Pretreatment with the HA synthesis inhibitor alpha-fluoromethyl-histidine administered intracerebroventricularly (i.c.v.) or intrape-ritoneally (i.p.) inhibited the ACTH and beta-END response to LPS about 60 %, whereas i.p. administration of the H3 receptor agonist R(alpha)methylHA, which inhibits HA synthesis and release, decreased the response about 50 %. Pretreatment with the H1 receptor antagonist mepyramine (67 micrograms x 2 i.c.v.) inhibited the hormone response to LPS about 50 %, while pretreatment with equimolar doses of the H2 receptor antagonists cime-tidine (67 micrograms x 2 i.c.v.) or ranitidine (83 micro-grams x 2 i.c.v.) had no effect on the LPS-induced release of ACTH and beta-END. When the H1 receptor antagonists mepyramine and cetirizine were administered i.p. in doses (10 mg/kg) which penetrate the blood-brain barrier the hormone response to LPS was inhibited 50 % and 30 %, respectively. Administered i.p. the H2 receptor antagonists had no effect on the hormone response to LPS. We conclude that hypothalamic histaminergic neurons in rats are involved in the mediation of the ACTH and beta-END response to LPS stimulation via activation of central postsynaptic H1 receptors.

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Eur J Pharmacol. 2002 Sep 13;451(2):149—55 Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions Seegers U, Potschka H, Loscher W Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17 Building 218, D-30559 Hannover, Germany P-glycoprotein is an ATP-dependent drug transport protein that is predominantly found in the apical membranes of various epithelial cell types in the body, including the blood luminar membrane of the brain capillary endothelial cellsthat make up the